Water → (4-Cyclopropylphenyl)methanol
反応式
[CH:1]1([C:4]2[CH:11]=[CH:10][C:7]([CH:8]=[O:9])=[CH:6][CH:5]=2)[CH2:3][CH2:2]1.[BH4-].[Li+].O>CO>[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([CH2:8][OH:9])=[CH:10][CH:11]=2)[CH2:2][CH2:3]1参加物
5
実験手順
To a solution of 4-cyclopropylbenzaldehyde (0.71 g) in methanol (10 mL) was added lithium borohydride (2 mol/L tetrahydrofuran solution, 3.7 mL), and the mixture was warmed to room temperature and stirred for 30 minutes. To the reaction mixture was added water, and the mixture was extracted with diethyl ether. The organic layer was washed with 1 mol/L hydrochloric acid solution and brine, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate=5/1) to give 4-cyclopropylbenzyl alcohol (0.69 g).
後処理
- extractionthe mixture was extracted with diethyl ether
- washThe organic layer was washed with 1 mol/L hydrochloric acid solution and brine
- dry with materialdried over anhydrous sodium sulfate
- customThe solvent was removed under reduced pressure
- customthe residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate=5/1)
出典と根拠
- ORDレコード
- ord-621039449c2a4a8292dc2cf8bcf28ed2
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07087579B2
反応ノート
読み込み中…