Piperazine → 3-Fluoro4-piperazin-1-yl-benzoic acid ethyl ester
反応式
[CH2:1]([O:3][C:4](=[O:13])[C:5]1[CH:10]=[CH:9][C:8](F)=[C:7]([F:12])[CH:6]=1)[CH3:2].[NH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>CN(C)C(=O)C>[CH2:1]([O:3][C:4](=[O:13])[C:5]1[CH:10]=[CH:9][C:8]([N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[C:7]([F:12])[CH:6]=1)[CH3:2]参加物
4
反応条件
- 温度
- 120 °C
実験手順
A mixture of 5 g (27 mmol) 3,4-Difluoro-benzoic acid ethyl ester and 11.56 g (134 mmol) piperazine in 15 ml N,N-dimethylacetamide was heated to 120° C. for 1.5 h and subsequently all volatiles were removed under vacuum. The residue was purified by flash column chromatography on silica eluting with DCM/methanol to yield 6.19 g (91%) of the title compound as white amorphous solid.
後処理
- customsubsequently all volatiles were removed under vacuum
- customThe residue was purified by flash column chromatography on silica eluting with DCM/methanol
出典と根拠
- ORDレコード
- ord-d7fae6fd54b6434a871830e431eedfd9
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07595314B2
反応ノート
読み込み中…