Morpholine → 2-Morpholin-4-yl-5-(pyrrolidine-1-sulfonyl)-benzoic acid

反応式

CS(C1C=CC(N2CCCC2)=C(C=1)C(O)=O)(=O)=O.Cl[C:20]1[CH:28]=[CH:27][C:26]([S:29]([N:32]2[CH2:36][CH2:35][CH2:34][CH2:33]2)(=[O:31])=[O:30])=[CH:25][C:21]=1[C:22]([OH:24])=[O:23].[NH:37]1[CH2:42][CH2:41][O:40][CH2:39][CH2:38]1>>[N:37]1([C:20]2[CH:28]=[CH:27][C:26]([S:29]([N:32]3[CH2:36][CH2:35][CH2:34][CH2:33]3)(=[O:31])=[O:30])=[CH:25][C:21]=2[C:22]([OH:24])=[O:23])[CH2:42][CH2:41][O:40][CH2:39][CH2:38]1

参加物

反応物 3

HCID 8083Morpholine

HCID 21198742-Chloro-5-(pyrrolidine-1-sulfonyl)benzoic acid

HCID 597934895-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid

生成物 1

HCID 597937192-Morpholin-4-yl-5-(pyrrolidine-1-sulfonyl)-benzoic acid収率 34%

実験手順

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid from 2-Chloro-5-(pyrrolidine-1-sulfonyl)-benzoic acid and morpholine and obtained in 34% yield. MS (m/e): 339.2 (MH−, 100%).

後処理

customobtained in 34% yield

出典と根拠

ORDレコード: ord-5fe328b5df27457d956e53aac50f49bc
出典データセット: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07595314B2

反応ノート

読み込み中…