tert-Butyl piperazine-1-carboxylate → 4-(2-Chloro-4-fluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

反応式

Br[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[Cl:9].[C:10]([N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11]>>[C:13]([O:12][C:10]([N:17]1[CH2:22][CH2:21][N:20]([C:2]2[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=2[Cl:9])[CH2:19][CH2:18]1)=[O:11])([CH3:16])([CH3:14])[CH3:15]

参加物

反応物 2

HCID 143452tert-Butyl piperazine-1-carboxylate

HCID 27334061-Bromo-2-chloro-4-fluorobenzene

生成物 1

HCID 597936054-(2-Chloro-4-fluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

実験手順

The title compound was prepared according to the procedure described for example AX from 1-bromo-2-chloro-4-fluorobenzene and N-Boc-piperazine (10%, off white solid, MS (m/e): 315.1 (M+H, 100%)

出典と根拠

ORDレコード: ord-eaebb2aff36149609cfb46c4bdae6a15
出典データセット: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07595314B2

反応ノート

読み込み中…