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HRID 736235作成日：2026年10月26日

2-cyclopropyl-1H-imidazole → [5-(2-Cyclopropyl-imidazol-1-yl)-2-morpholin-4-yl-phenyl]-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone

https://huagongshe.com/reaction/736235

反応式

関与物質

役割名称HCID仕込み量
反応物2-cyclopropyl-1H-imidazoleHCID 17942383—
反応物(5-Bromo-2-morpholin-4-yl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanoneHCID 59793730—
生成物[5-(2-Cyclopropyl-imidazol-1-yl)-2-morpholin-4-yl-phenyl]-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanoneHCID 6884191716%

反応手順

The title compound was prepared according to the procedure described for example 199 from (5-Bromo-2-morpholin-4-yl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone (compound CR) and 2-Cyclopropyl-1H-imidazole (CAS: 89532-38-7) (16% yield, white solid, MS (m/e): 526.3 (M+H, 100%)

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07595314B2
出典データセットuspto-grants-2009_09
ORD IDord-079f3da0462b4aa58a68ba1f2444ec9f
出典メモuspto-grants-2009_09