tert-Butyl piperazine-1-carboxylate → tert-Butyl 4-[2-(trifluoromethyl)pyrimidin-5-yl]piperazine-1-carboxylate

HRID 736248

反応式

HRID 736248 の反応式
Cl[C:2]1[CH:3]=[N:4][C:5]([C:8]([F:11])([F:10])[F:9])=[N:6][CH:7]=1.[C:12]([O:16][C:17]([N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)=[O:18])([CH3:15])([CH3:14])[CH3:13]>CC(N(C)C)=O>[C:12]([O:16][C:17]([N:19]1[CH2:24][CH2:23][N:22]([C:2]2[CH:3]=[N:4][C:5]([C:8]([F:11])([F:10])[F:9])=[N:6][CH:7]=2)[CH2:21][CH2:20]1)=[O:18])([CH3:15])([CH3:13])[CH3:14]

参加物

4

反応物 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 336979605-Chloro-2-(trifluoromethyl)pyrimidine

生成物 1

HCID 53485514tert-Butyl 4-[2-(trifluoromethyl)pyrimidin-5-yl]piperazine-1-carboxylate

試薬・触媒・溶媒 1

HCID 31374Dimethylacetamide溶媒

反応条件

温度
15 °C

実験手順

0.26 mmol 5-Chloro-2-trifluoromethyl-pyrimidine was added to 0.26 mmol piperazine-1-carboxylic acid tert-butyl ester in 1.5 ml dimethylacetamide and the reaction mixture was stirred at 15° C. for 10 min. in a microwave oven. After such time the reaction mixture was concentrated and the residue was then purified by column chromatography (SiO2, Heptane/EtOAc) to yield the title compound. MS (m/e): 333.2 (M+H+, 100%)

後処理

  1. concentrationAfter such time the reaction mixture was concentrated
  2. customthe residue was then purified by column chromatography (SiO2, Heptane/EtOAc)

出典と根拠

ORDレコード
ord-c71d4e82cf104e5db0be7b290dab41ec
出典データセット
uspto-grants-2009_09
特許番号
US07595314B2

関連ノート

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