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Methanesulfonic Acid → 4-(4-methylpiperazin-1-ylaminomethyl)-N-[2-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide methanesulfonate

HRID 736307
ノート
印刷プレビュー

反応式

HRID 736307 の反応式
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([NH:8][CH2:9][C:10]2[CH:38]=[CH:37][C:13]([C:14]([NH:16][C:17]3[CH:22]=[C:21]([NH:23][C:24]4[N:29]=[C:28]([C:30]5[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=5)[CH:27]=[CH:26][N:25]=4)[CH:20]=[CH:19][C:18]=3[CH3:36])=[O:15])=[CH:12][CH:11]=2)[CH2:4][CH2:3]1.[CH3:39][S:40]([OH:43])(=[O:42])=[O:41]>C(O)C>[CH3:39][S:40]([OH:43])(=[O:42])=[O:41].[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([NH:8][CH2:9][C:10]2[CH:38]=[CH:37][C:13]([C:14]([NH:16][C:17]3[CH:22]=[C:21]([NH:23][C:24]4[N:29]=[C:28]([C:30]5[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=5)[CH:27]=[CH:26][N:25]=4)[CH:20]=[CH:19][C:18]=3[CH3:36])=[O:15])=[CH:12][CH:11]=2)[CH2:4][CH2:3]1
参加物実験手順後処理出典と根拠反応ノート

参加物

4

反応物 2

HCID 6395Methanesulfonic AcidHCID 688169564-(4-methylpiperazin-1-ylaminomethyl)-N-[2-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide

生成物 1

HCID 865953424-(4-methylpiperazin-1-ylaminomethyl)-N-[2-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide methanesulfonate収率 69.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

4-(4-Methylpiperazin-1-ylaminomethyl)-N-[2-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide (1.7 g, 3.42 mmol) was dissolved in ethanol (25 ml), methanesulfonic acid (222 μl, 3.42 mmol) was added, and the mixture was reacted at room temperature for 18 hours. The resulting solid was filtered and washed with acetone to give 4-(4-methylpiperazin-1-ylaminomethyl)-N-[2-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide methanesulfonate (1.43 g).

後処理

  1. customthe mixture was reacted at room temperature for 18 hours
  2. filtrationThe resulting solid was filtered
  3. washwashed with acetone

出典と根拠

ORDレコード
ord-20a888a54aa64a35aa343f5a7a7f4bf8
出典データセット
uspto-grants-2009_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07595323B2

反応ノート

読み込み中…

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