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Ammonium → 4-chloro-1H-pyrrole-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonium | HCID 223 | — |
| 反応物 | 2,2,2-trichloro-1-(4-chloro-1H-pyrrol-2-yl)ethan-1-one | HCID 7130688 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-chloro-1H-pyrrole-2-carboxamide | HCID 55207577 | 92% |
反応手順
A solution of 2,2,2-trichloro-1-(4-chloro-1H-Pyrrol-2-yl)ethanone (14.0 g, 56.7 mmol) in THF (100 mL) was bubbled with ammonium gas for 2 h at room temperature. TLC analysis indicated that there was complete conversion of starting material. The reaction mixture was concentrated in vacuo to yield 7.5 g of the above compound (51.88 mmol, yield 92%). 1H-NMR (Acetone-d6) δ 10.92 (br s, 1H), 7.21 (br s, 1H), 7.02 (s, 1H), 6.84 (s, 1H), 6.57 (br s, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829185B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-b8bc12b6e8904d4c98cd4a08ecec8f0b |
| 出典メモ | uspto-grants-2014_09 |