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3-(6-Methoxy-cyclohex-1-enyl)-1H-indole → 3-(2-Methoxy-cyclohexyl)-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(6-Methoxy-cyclohex-1-enyl)-1H-indole | HCID 58975073 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 3-(2-Methoxy-cyclohexyl)-1H-indole | HCID 58975094 | 63% |
反応手順
Treat 3-(6-methoxy-cyclohex-1-enyl)-1H-indole (200 mg, 0.879 mmol) with 10% Pd/C (40 mg) in EtOAc under atmospheric hydrogenation conditions for 1.5 hours. Filter resulting solution over Celite to remove catalyst. Concentrate crude on rotovap and purify on silica gel chromatography to give 3-(2-Methoxy-cyclohexyl)-1H-indole (127 mg, 63% yield). Mass Spectrum (m/e): 230.03 (MH+), 228.14 (M−).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07595339B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-683d20d846bf496d957543d5f33f089d |
| 出典メモ | uspto-grants-2009_09 |