Triphenylphosphine → HCID 57849580、化合物

HRID 737071ノート

反応式

HRID 737071 の反応式
[C:1]([O:5][C:6](=[O:20])[N:7]([CH2:17][CH2:18][OH:19])[CH2:8][C@@H:9](O)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH3:4])([CH3:3])[CH3:2].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CCOC(/N=N/C(OCC)=O)=O>C1(C)C=CC=CC=1>[C:1]([O:5][C:6]([N:7]1[CH2:17][CH2:18][O:19][C@@H:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:8]1)=[O:20])([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 11776TriphenylphosphineHCID 5462977Diethyl azodicarboxylateHCID 57849526HCID 57849526、化合物

生成物 1

HCID 57849580HCID 57849580、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

3 g of (S)-(2-Hydroxy-ethyl)-(2-hydroxy-2-phenyl-ethyl)-carbamic acid tert-butyl ester and 0.327 g of triphenylphosphine were dissolved in 53.3 mL toluene. 0.217 g of diethylazodicarboxylate in 5.4 mL toluene was added dropwise to the resulting solution at room temperature under argon atmosphere and the mixture was stirred overnight. The solvent was removed in vacuo and the material purified by column chromatography.

後処理

  1. customThe solvent was removed in vacuo
  2. customthe material purified by column chromatography

出典と根拠

ORDレコード
ord-8efce4b635e24607bf033927a87c1ce0
出典データセット
uspto-grants-2009_09
特許番号
US07595397B2

反応ノート

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