Sodium Acetate → 2-Amino-4-(p-nitrophenyl)thiazole

HRID 737156ノート

反応式

HRID 737156 の反応式
[NH2:1][C:2]([NH2:4])=[S:3].[C:5]([O-])(=O)[CH3:6].[Na+].BrCC(O)=O.[N+:15]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([O-:17])=[O:16]>C(O)C>[N+:15]([C:18]1[CH:23]=[CH:22][C:21]([C:5]2[N:1]=[C:2]([NH2:4])[S:3][CH:6]=2)=[CH:20][CH:19]=1)([O-:17])=[O:16]

参加物

5

反応物 3

HCID 517045Sodium AcetateHCID 2723790ThioureaHCID 86616428Nitrobenzene bromoacetate

生成物 1

HCID 164202-Amino-4-(p-nitrophenyl)thiazole

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1.0 g (13.2 mmol) of thiourea, sodium acetate (2.2 g 26.4 mmol), and 25 mL of dry ethanol were combined in a 25 mL round bottom flask. To this suspension was added nitrobenzene bromoacetate (4.2 g, 1.72 mmol). Reaction mixture was heated under reflux overnight. This suspension was cooled to room temperature. The solid was collected by suction filtration and washed using water. The resulting solid was dried to yield 4-(4-nitro-phenyl)-thiazol-2-ylamine. MS: 222.1 (M+H+).

後処理

  1. customReaction mixture
  2. temperaturewas heated
  3. temperatureunder reflux overnight
  4. filtrationThe solid was collected by suction filtration
  5. washwashed
  6. customThe resulting solid was dried

出典と根拠

ORDレコード
ord-8a16edf569124b38bd4b712354421325
出典データセット
uspto-grants-2009_09
特許番号
US07595398B2

反応ノート

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