関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzyl chloroformate | HCID 10387 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | L-Thioproline | HCID 93176 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | (R)-3-((Benzyloxy)carbonyl)thiazolidine-4-carboxylic acid | HCID 11119045 | — |
反応手順
(R)-Thiazolidine-4-carboxylic acid (309.9 mg, 2.33 mmol) was dissolved in DMF (10 mL) and distilled water (10 mL). The solution was cooled to 0° C., and DIEA (0.590 mL, 3.39 mmol) was added followed by benzyl chloroformate (0.485 mL, 3.40 mmol). The reaction was stirred at 0° C. and allowed to warm to ambient temperature overnight. The reaction was filtered and purified by reverse phase HPLC to give the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07595398B2 |
|---|
| 出典データセット | uspto-grants-2009_09 |
|---|
| ORD ID | ord-aa810961bef348658de3df2fc279b3f4 |
|---|
| 出典メモ | uspto-grants-2009_09 |
|---|
