Cyclopentylamine → 4-(2-Bromo-acetyl)-N-cyclopentyl-benzenesulfonamide

HRID 737193ノート

反応式

HRID 737193 の反応式
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([S:11](Cl)(=[O:13])=[O:12])=[CH:7][CH:6]=1)=[O:4].C(N(CC)CC)C.[CH:22]1([NH2:27])[CH2:26][CH2:25][CH2:24][CH2:23]1>ClCCl>[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:27][CH:22]2[CH2:26][CH2:25][CH2:24][CH2:23]2)(=[O:13])=[O:12])=[CH:7][CH:6]=1)=[O:4]

参加物

5

反応物 3

HCID 2906CyclopentylamineHCID 8471TriethylamineHCID 27568344-(2-bromoacetyl)benzenesulfonyl Chloride

生成物 1

HCID 866164394-(2-Bromo-acetyl)-N-cyclopentyl-benzenesulfonamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

4-(2-Bromo-acetyl)-benzenesulfonyl chloride (150 mg, 0.17 mmol) was dissolved in 4 mL of dry dichloromethane. To this solution at 0° C., was added triethylamine (0.03 mL, 0.2 mmol), followed by cyclopentylamine (0.2 mmol, 0.011 g). Reaction mixture was stirred at 0° C. for 15 minutes and then quenched with H2O. The reaction mixture was extracted with H2O. The organic phase was isolated, dried over MgSO4 and evaporated. It was used in the next step without any further purification.

後処理

  1. customReaction mixture
  2. customquenched with H2O
  3. extractionThe reaction mixture was extracted with H2O
  4. customThe organic phase was isolated
  5. dry with materialdried over MgSO4
  6. customevaporated
  7. customIt was used in the next step without any further purification

出典と根拠

ORDレコード
ord-61fd7bb351d74546ab036ec16a3e0970
出典データセット
uspto-grants-2009_09
特許番号
US07595398B2

反応ノート

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