Sodium Acetate → 4-(2-Amino-thiazol-4-yl)-N-cyclopentyl-benzenesulfonamide
反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:14][CH:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)(=[O:13])=[O:12])=[CH:7][CH:6]=1)=O.[NH2:20][C:21]([NH2:23])=[S:22].CC([O-])=O.[Na+]>CCO>[NH2:23][C:21]1[S:22][CH:2]=[C:3]([C:5]2[CH:10]=[CH:9][C:8]([S:11]([NH:14][CH:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)(=[O:13])=[O:12])=[CH:7][CH:6]=2)[N:20]=1参加物
5
実験手順
4-(2-Bromo-acetyl)-N-cyclopentyl-benzenesulfonamide (150 mg, 0.43 mmol) was combined with thiourea (33 mg, 0.43 mmol) in 7 ml of dry EtOH. To this solution was added NaOAc (53 mg, 0.65 mmol). Reaction mixture was stirred at room temperature for 4 hours. Reaction mixture was evaporated to dryness and used in the next step without further purification.