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(3S)-3-Pyrrolidinemethanol → (S)-5-Bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-(hydroxymethyl)pyrrolidin-1-yl)nicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (3S)-3-Pyrrolidinemethanol | HCID 7446911 | — |
| 反応物 | 5-bromo-6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)nicotinamide | HCID 72546089 | — |
| 生成物 | (S)-5-Bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-(hydroxymethyl)pyrrolidin-1-yl)nicotinamide | HCID 86702603 | — |
反応手順
The title compound was prepared in an analogous fashion to that described in Stage 9.2 using 5-bromo-6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)nicotinamide (Stage 9.3) and (S)-1-pyrrolidin-3-yl-methanol to afford an off-white crystalline solid. HPLC (Condition 4) tR5.82 min, UPLC-MS (Condition 3) tR=1.14 min, m/z=476.2/478.3 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829195B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-9b3cc4673186459791f4a4d561e6b87c |
| 出典メモ | uspto-grants-2014_09 |