5-Bromo-6-chloropyridine-3-carboxylic acid → 5-bromo-6-chloro-N-(4-(perfluoroethyl)phenyl)nicotinamide

HRID 73769

反応式

HRID 73769 の反応式
[Br:1][C:2]1[C:3]([Cl:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[F:12][C:13]([F:25])([C:18]1[CH:24]=[CH:23][C:21]([NH2:22])=[CH:20][CH:19]=1)[C:14]([F:17])([F:16])[F:15]>>[Br:1][C:2]1[C:3]([Cl:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([NH:22][C:21]1[CH:20]=[CH:19][C:18]([C:13]([F:12])([F:25])[C:14]([F:15])([F:16])[F:17])=[CH:24][CH:23]=1)=[O:9]

参加物

3

反応物 2

HCID 2854335-Bromo-6-chloropyridine-3-carboxylic acidHCID 137504454-(Pentafluoroethyl)aniline

生成物 1

HCID 867026145-bromo-6-chloro-N-(4-(perfluoroethyl)phenyl)nicotinamide

実験手順

The title compound was prepared in an analogous fashion to that described in Stage 11.2 using 5-bromo-6-chloro-nicotinic acid and 4-pentafluoroethyl-aniline to afford a white crystalline solid. HPLC (Condition 4) tR=6.61 min, UPLC-MS (Condition 3) tR=1.32 min, m/z=429 [M−H]−.

後処理

  1. customto afford a white crystalline solid

出典と根拠

ORDレコード
ord-7960dd31f1db4e9b9ea4d410a00d6e98
出典データセット
uspto-grants-2014_09
特許番号
US08829195B2

関連ノート

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