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5-Bromo-6-chloropyridine-3-carboxylic acid → 5-bromo-6-chloro-N-(4-((chlorodifluoromethyl)thio)phenyl)nicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Bromo-6-chloropyridine-3-carboxylic acid | HCID 285433 | — |
| 反応物 | HCID 56624957 | HCID 56624957 | — |
| 生成物 | 5-bromo-6-chloro-N-(4-((chlorodifluoromethyl)thio)phenyl)nicotinamide | HCID 86702618 | — |
反応手順
The title compound was prepared in an analogous fashion to that described in Stage 11.2 using 5-bromo-6-chloro-nicotinic acid and 4-((chloro-difluoromethyl)thio)aniline (Stage 18.3) to afford an off-white crystalline solid. HPLC (Condition 4) tR=6.78 min, UPLC-MS (Condition 3) tR=1.32 min, m/z=425 [M−H]−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829195B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-2e20c9ebd32648309d5f92851d6f7241 |
| 出典メモ | uspto-grants-2014_09 |