5-Bromo-6-chloropyridine-3-carboxylic acid → 5-bromo-6-chloro-N-(4-(perfluoroethoxy)phenyl)nicotinamide
反応式
[Br:1][C:2]1[C:3]([Cl:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[F:12][C:13]([F:26])([O:18][C:19]1[CH:25]=[CH:24][C:22]([NH2:23])=[CH:21][CH:20]=1)[C:14]([F:17])([F:16])[F:15]>>[Br:1][C:2]1[C:3]([Cl:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([NH:23][C:22]1[CH:21]=[CH:20][C:19]([O:18][C:13]([F:12])([F:26])[C:14]([F:15])([F:16])[F:17])=[CH:25][CH:24]=1)=[O:9]参加物
3
実験手順
The title compound was prepared in an analogous fashion to that described in Stage 9.3 using 5-bromo-6-chloro-nicotinic acid and 4-(perfluoroethoxy)aniline to afford an off-white crystalline solid. HPLC (Condition 4) tR=6.73 min, UPLC-MS (Condition 3) tR=1.30 min, m/z=443.1 [M−H]−.
後処理
- customto afford an off-white crystalline solid
出典と根拠
- ORDレコード
- ord-9cd77a866ae34b0c9f90ca13a7d7513f
- 出典データセット
- uspto-grants-2014_09