3-Bromo-4-fluorobenzoic acid → 3-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-4-fluorobenzamide

HRID 73781

反応式

HRID 73781 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([OH:7])=O.[Cl:12][C:13]([F:23])([F:22])[O:14][C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=1>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([NH:19][C:18]1[CH:20]=[CH:21][C:15]([O:14][C:13]([Cl:12])([F:22])[F:23])=[CH:16][CH:17]=1)=[O:7]

参加物

3

反応物 2

HCID 705093-Bromo-4-fluorobenzoic acidHCID 5727934-(Chlorodifluoromethoxy)aniline

生成物 1

HCID 867026223-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-4-fluorobenzamide

実験手順

The title compound was prepared in an analogous fashion to that described in Stage 1.3 using 3-bromo-4-fluorobenzoic acid and 4-(chlorodifluoromethoxy)aniline to afford an off-white solid. UPLC-MS (Condition 3) tR=1.25 min, m/z=394.0 [M+H]+, m/z=391.9 [M−H]−; 1H NMR (400 MHz, DMSO-d6) δ ppm 7.37 (d, J=9.17 Hz, 2H) 7.57 (t, J=8.68 Hz, 1H) 7.84-7.91 (m, 2H) 8.03 (ddd, J=8.62, 4.83, 2.32 Hz, 1H) 8.32 (dd, J=6.60, 2.20 Hz, 1H) 10.52 (s, 1H).

後処理

  1. customto afford an off-white solid

出典と根拠

ORDレコード
ord-d538fe0b1c824ebcae8938eee4d4afca
出典データセット
uspto-grants-2014_09
特許番号
US08829195B2

関連ノート

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