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(3S)-pyrrolidin-3-ol → (S)-5-bromo-6-(3-hydroxypyrrolidin-1-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (3S)-pyrrolidin-3-ol | HCID 2733874 | — |
| 反応物 | 5-bromo-6-chloro-N-(4-(trifluoromethoxy)phenyl)nicotinamide | HCID 86702595 | — |
| 生成物 | (S)-5-bromo-6-(3-hydroxypyrrolidin-1-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide | HCID 86702636 | — |
反応手順
The title compound was prepared in an analogous fashion to that described in Stage 8.1 using 5-bromo-6-chloro-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 2.3) and (S)-pyrrolidin-3-ol to afford an off-white crystalline powder. HPLC (Condition 4) tR=5.83 min, UPLC-MS (Condition 3) tR=1.06 min, m/z=446.1 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829195B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-7f8fe8431301407aa3b316be3ef96699 |
| 出典メモ | uspto-grants-2014_09 |