Hydrogen chloride-ethyl acetate → 1-[[[4-(4-Propylpiperazin-1-yl)phenyl]carbonyl]amino]cyclohexanecarboxylic acid methyl ester hydrochloride

HRID 73835ノート

反応式

HRID 73835 の反応式
[ClH:1].C(OCC)(=O)C.[CH3:8][O:9][C:10]([C:12]1([NH:18][C:19]([C:21]2[CH:26]=[CH:25][C:24]([N:27]3[CH2:32][CH2:31][N:30]([CH2:33][CH2:34][CH3:35])[CH2:29][CH2:28]3)=[CH:23][CH:22]=2)=[O:20])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=[O:11]>C(OCC)(=O)C>[ClH:1].[CH3:8][O:9][C:10]([C:12]1([NH:18][C:19]([C:21]2[CH:26]=[CH:25][C:24]([N:27]3[CH2:32][CH2:31][N:30]([CH2:33][CH2:34][CH3:35])[CH2:29][CH2:28]3)=[CH:23][CH:22]=2)=[O:20])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=[O:11]

参加物

4

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 576728301-[[[4-(4-Propylpiperazin-1-yl)phenyl]carbonyl]amino]cyclohexanecarboxylic acid methyl ester

生成物 1

HCID 671820191-[[[4-(4-Propylpiperazin-1-yl)phenyl]carbonyl]amino]cyclohexanecarboxylic acid methyl ester hydrochloride収率 66%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

1 ml of 4N hydrochloric acid/ethyl acetate solution was added to a solution of 120 mg (0.31 mmol) of 1-[[[4-(4-propylpiperazin-1-yl)phenyl]carbonyl]amino]cyclohexanecarboxylic acid methyl ester in 10 ml of ethyl acetate, and the mixture was stirred at room temperature for 30 minutes. The precipitated crystal was collected by filtration to obtain 87 mg (66%) of the title compound.

後処理

  1. filtrationThe precipitated crystal was collected by filtration

出典と根拠

ORDレコード
ord-0729de170b934248a23959806a4bdd51
出典データセット
uspto-grants-2014_09
特許番号
US08829209B2

反応ノート

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