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Water → N-[[1-[(2-Benzothienylcarbonyl)amino]cyclohexyl]carbonyl]-L-methioninol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | L-Methioninol | HCID 2724404 | — |
| 反応物 | 2-(2-Benzothienyl)-3-oxa-1-azaspiro[4.5]dec-1-en-4-one | HCID 57672854 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-[[1-[(2-Benzothienylcarbonyl)amino]cyclohexyl]carbonyl]-L-methioninol | HCID 57672844 | 98.1% |
反応手順
284 mg (2.1 mmol) of L-methioninol was added to a solution of 500 mg (1.75 mmol) of 2-(2-benzothienyl)-3-oxa-1-azaspiro[4.5]dec-1-en-4-one in 3 ml of N,N-dimethylformamide, and the mixture was stirred overnight. Water was slowly added and the precipitated crystal was collected by filtration. The obtained crystal was dried under reduced pressure to obtain 722 mg (98%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829209B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-9916fdb5818e47fface6418a8a6b2b93 |
| 出典メモ | uspto-grants-2014_09 |