化工社化工社 化学情報印刷レポート · 研究参考用
2-Tert-Butylphenol → 4-Bromo-2-tert-butylphenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Tert-Butylphenol | HCID 6923 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-Bromo-2-tert-butylphenol | HCID 97068 | 99.3% |
反応手順
To a solution of 2-tert-butylphenol (250 g, 1.67 mol) in CH3CN (1500 mL) was added NBS (300 g, 1.67 mol) at room temperature. After addition, the mixture was stirred at room temperature overnight and then the solvent was removed. Petroleum ether (1000 mL) was added, and the resulting white precipitate was filtered off. The filtrate was concentrated under reduced pressure to give the crude 2-tert-butyl-4-bromophenol (380 g), which was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829204B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-97ca45fe2d5043acb3e89dba7009a4e9 |
| 出典メモ | uspto-grants-2014_09 |