Acetic acid, 2-oxo-, methyl ester → methyl (2E)-2-[(2-chlorophenyl)hydrazinylidene]acetate

HRID 7404

反応式

HRID 7404 の反応式
[C:1]([O:5][CH3:6])(=[O:4])[CH:2]=O.Cl.[Cl:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH:15][NH2:16]>CO>[Cl:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH:15]/[N:16]=[CH:2]/[C:1]([O:5][CH3:6])=[O:4]

参加物

4

反応物 2

HCID 70205Acetic acid, 2-oxo-, methyl esterHCID 4432872-Chlorophenylhydrazine hydrochloride

生成物 1

HCID 19868318methyl (2E)-2-[(2-chlorophenyl)hydrazinylidene]acetate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of methyl glyoxylate (6.8 g, 77 mmol) in methanol (150 mL) was added 2-chlorophenylhydrazine hydrochloride (12.5 g, 77 mmol) and the mixture was heated at reflux overnight, cooled and concentrated. The residue was re-dissolved in toluene and concentrated to give the title compound of Step A.

後処理

  1. temperaturethe mixture was heated
  2. temperatureat reflux overnight
  3. temperaturecooled
  4. concentrationconcentrated
  5. dissolutionThe residue was re-dissolved in toluene
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-a1a53def4c664a96999097c0e8311779
出典データセット
uspto-grants-2006_08
特許番号
US07087598B2

関連ノート

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