化工社化工社 化学情報印刷レポート · 研究参考用
Pamidronic Acid → Alendronic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pamidronic Acid | HCID 4674 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Alendronic Acid | HCID 2088 | — |
反応手順
The NHS ester (0.35 g, 0.62 mmol) was dissolved in H2O (30 mL), and pamidronate (0.52 g, 2.23 mmol) and Et3N (1.7 mL, 12.4 mmol) were added. The reaction solution was stirred for 24 h at room temperature. Subsequently, the H2O was removed in the vacuum. The product obtained was purified by means of HPLC.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829233B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-63709912d71b4b3b8f382421cafd90e3 |
| 出典メモ | uspto-grants-2014_09 |