Acetic Anhydride → 5-Chloro-2-methyl-4H-3,1-benzoxazin-4-one
反応式
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[C:3]=1[C:4]([OH:6])=[O:5].[C:12](OC(=O)C)(=O)[CH3:13]>>[Cl:11][C:7]1[C:3]2[C:4](=[O:6])[O:5][C:12]([CH3:13])=[N:1][C:2]=2[CH:10]=[CH:9][CH:8]=1参加物
3
反応条件
- 温度
- 120 °C
実験手順
2-amino-6-chlorobenzoic acid (25 g) dissolved in acetic anhydride (100 ml) was stirred at 120° C. for 2 hours. The mixture was cooled to room temperature and filtered off. The precipitate was washed with water and Na2CO3 (10%) and dissolved in CH2Cl2. The solution was dried with Na2SO4, filtered off and evaporated. The residue was crystallized twice from benzene, yielding 13 g (46%) of 5-chloro-2-methyl-4H-3,1-benzoxazin-4-one; mp. 148.7° C. (interm. 14).
後処理
- temperatureThe mixture was cooled to room temperature
- filtrationfiltered off
- washThe precipitate was washed with water and Na2CO3 (10%)
- dissolutiondissolved in CH2Cl2
- dry with materialThe solution was dried with Na2SO4
- filtrationfiltered off
- customevaporated
- customThe residue was crystallized twice from benzene
出典と根拠
- ORDレコード
- ord-b5389765c6734447ac5744451fc56370
- 出典データセット
- uspto-grants-1996_09
- 特許番号
- US05552399
反応ノート
読み込み中…