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Hydrogen Bromide → 7-bromo-4-(bromoacetyl)-2H-chromen-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 7-bromo-4-(1-ethoxyvinyl)-2H-chromen-2-one | HCID 23370204 | — |
| 反応物 | Sodium Bisulfite | HCID 23665763 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 溶媒 | Acetonitrile--water (1/1) | HCID 18373917 | — |
| 生成物 | 7-bromo-4-(bromoacetyl)-2H-chromen-2-one | HCID 23370239 | — |
反応手順
To a solution of vinyl ether from Step 1 (1.02 g) in CH3CN:H2O 4:1 (25 mL) were successively added NBS (0.82 g) and concentrated HBr (20 μL). After being stirred at r.t. for 4 h, the reaction mixture was treated with 5% aqueous NaHSO3 (1 mL). Ethyl acetate was then added and the organic phase was washed with saturated aqueous NaHCO3, H2O and brine, dried (MgSO4) and evaporated. Flash chromatography of the residue (silica gel; hexane/EtOAc (85:15)) afforded the title compound as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05552437 |
| 出典データセット | uspto-grants-1996_09 |
| ORD ID | ord-33c10a59f86a4b8dbee8b2a4e829a096 |
| 出典メモ | uspto-grants-1996_09 |