関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | 4-Methyl-7-diethylaminocoumarin | HCID 7050 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | Trifluoromethanesulfonic anhydride | HCID 67749 | — |
| 生成物 | 3-Cyano-1-(furan-3-yl)-6-(trifluoromethanesulfonyloxy)naphthalene | HCID 11793313 | — |
反応手順
To a solution of the Naphthalene 1 (565 mg, 2.40 mmol) in CH2Cl2 (16 mL) at 0° C. was added pyridine (380 mg, 4.80 mmol, 389 μL) and triflic anhydride (813 mg, 2.88 mmol, 485 μL). The solution was stirred at 0° C. for 2.5 h and then poured into sat. aq. NH4Cl. The layers were separated and the aq. phase extracted with EtOAc (3×30 mL). The combined organic layers were washed with 5% aq. HCl, 5% aq. NaHCO3, brine, and dried over anhydrous MgSO4. Evaporation of the solvent gave a solid (810 mg) which was used directly in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05552437 |
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| 出典データセット | uspto-grants-1996_09 |
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| ORD ID | ord-00502421e23949cf8b6bee1b9f1c1767 |
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| 出典メモ | uspto-grants-1996_09 |
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