HCID 10647114、化合物 → 2(R)-[[4methoxybenzenesulfonyl](benzyl)amino]-4-methylpentanoic acid

HRID 742025ノート

反応式

HRID 742025 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]([CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C@H:13]([CH2:21][CH:22]([CH3:24])[CH3:23])[C:14]([O:16]C(C)(C)C)=[O:15])(=[O:11])=[O:10])=[CH:5][CH:4]=1>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([S:9]([N:12]([CH2:25][C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[C@H:13]([CH2:21][CH:22]([CH3:24])[CH3:23])[C:14]([OH:16])=[O:15])(=[O:11])=[O:10])=[CH:7][CH:8]=1

参加物

3

反応物 1

HCID 10647114HCID 10647114、化合物

生成物 1

HCID 117948032(R)-[[4methoxybenzenesulfonyl](benzyl)amino]-4-methylpentanoic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

t-Butyl 2(R)-[[4-methoxybenzenesulfonyl](benzyl)amino]-4-methylpentan oate (5.38 g, 12.02 mmol) is dissolved in methylene chloride (100.0 mL). Hydrochloric acid gas (from a lecture bottle) is bubbled through the solution for 20 minutes. The reaction is sealed and stirred overnight at room temperature, The solvent is then evaporated to give 2(R)-[[4methoxybenzenesulfonyl](benzyl)amino]-4-methylpentanoic acid.

後処理

  1. customHydrochloric acid gas (from a lecture bottle) is bubbled through the solution for 20 minutes
  2. customThe reaction is sealed
  3. customThe solvent is then evaporated

出典と根拠

ORDレコード
ord-e43e2a935ec149bc8dc834ab189d35cb
出典データセット
uspto-grants-1996_09
特許番号
US05552419

反応ノート

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