N-Carbethoxyphthalimide → 5-Phthalimido-1-pentanol

HRID 742120

反応式

HRID 742120 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][OH:7].C(N1[C:17](=[O:18])[C:16]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]2[C:14]1=[O:23])(OCC)=O>C1C=CC=CC=1>[C:14]1(=[O:23])[N:1]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][OH:7])[C:17](=[O:18])[C:16]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]12

参加物

4

反応物 2

HCID 31187N-CarbethoxyphthalimideHCID 756345-Aminopentan-1-ol

生成物 1

HCID 5948445-Phthalimido-1-pentanol収率 84%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

To a solution of 5-amino-1-pentanol (5.00 g, 48.5 mmol) in benzene (150 mL) was added N-carboethoxyphthalimide (11.0 g, 50.2 mmol) and the solution was stirred at room temperature for 5 h). The solvents were removed under reduced pressure to yield a yellow oil. Purification by flash column chromatography using 25% ethyl acetate in petroleum ether yielded the target compound as a clear colorless oil (9.6 mg, 84%).

後処理

  1. customThe solvents were removed under reduced pressure
  2. customto yield a yellow oil
  3. customPurification by flash column chromatography

出典と根拠

ORDレコード
ord-2bf7a8b3504e4ac28b60b0de00b6f0b9
出典データセット
uspto-grants-1996_09
特許番号
US05552534

関連ノート

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