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Triethylamine → 3-(2,6-Diisopropylphenyl)-1-methyl-2-thioxo-imidazolidin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Isothiocyanato-1,3-bis(propan-2-yl)benzene | HCID 141194 | — |
| 反応物 | Ethyl N-methylaminoacetate hydrochloride | HCID 171173 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 3-(2,6-Diisopropylphenyl)-1-methyl-2-thioxo-imidazolidin-4-one | HCID 85701468 | 60.2% |
反応手順
The title compound was prepared by the procedure described in Example 1 using 8.3 g of 2,6-diisopropylphenyl-isothiocyanate, 5.8 g of sarcosine ethyl ester hydrochloride, 14.5 g of triethyl amine, and 200 mL of chloroform. Crystallization from diethyl ether/hexane mixture afforded the title compound (6.6 g) as a tan solid, m.p. 174°-176° C. Anal. Calcd. for C16H22N2O S: C, 66.17; H, 7.63; N, 9.64. Found: C, 66.39; H, 7.63; N, 9.59. Mass spectrum (+FAB, [M+H]+) m/z 269/271.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05554607 |
| 出典データセット | uspto-grants-1996_09 |
| ORD ID | ord-362b1f6739e240bb88908bd4ef3d3d4a |
| 出典メモ | uspto-grants-1996_09 |