Triethylamine → HCID 19069746、化合物
反応式
[CH2:1]([NH:3][CH2:4][C:5]([OH:7])=O)[CH3:2].[F:8][C:9]1[CH:18]=[CH:17][C:12]([CH2:13][N:14]=[C:15]=[S:16])=[CH:11][CH:10]=1.C(N(CC)CC)C>C(Cl)Cl>[CH2:1]([N:3]1[CH2:4][C:5](=[O:7])[N:14]([CH2:13][C:12]2[CH:17]=[CH:18][C:9]([F:8])=[CH:10][CH:11]=2)[C:15]1=[S:16])[CH3:2]参加物
5
実験手順
The title compound was prepared by the procedure described in Example 19 using 9.2 g of N-ethyl glycine, 8.4 g of 4-fluorobenzyl-isothiocyanate, 10.1 g of triethylamine, and 150 mL of methylene chloride. Purification was achieved through crystallization from ethyl acetate/hexane mixture. Title compound (4.85 g) was obtained as a white solid, m.p. 73°-76° C. Anal. Calcd. for. C12H13F N2O S: C, 57.12; H, 5.19; N, 11.10 Found: C, 56.97; H,5.15; N, 11.06. Mass spectrum (EI, M.+) m/z 252.
後処理
- customThe title compound was prepared by the procedure
- customPurification
- customwas achieved through crystallization from ethyl acetate/hexane mixture
出典と根拠
- ORDレコード
- ord-8ea02a19b9a849718f5387ade8eb2e4f
- 出典データセット
- uspto-grants-1996_09
- 特許番号
- US05554607
反応ノート
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