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Triethylamine → 3-(2,5-Dimethylphenyl)-1-ethyl-2-thioxo-imidazolidin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2,5-Dimethylphenyl isothiocyanate | HCID 140499 | — |
| 反応物 | N-Ethylglycine | HCID 316542 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 3-(2,5-Dimethylphenyl)-1-ethyl-2-thioxo-imidazolidin-4-one | HCID 11817510 | 42.7% |
反応手順
The title compound was prepared by the procedure described in Example 16 using 16.3 g of 2,5-dimethylphenyl-isothiocyanate, 18.4 g of N-ethyl glycine, 20.2 g of triethyl amine, and 250 mL of chloroform. Crystallization from ethyl acetate afforded the title compound (10.6 g) as an off-white solid, m.p. 176°-178° C. Anal. Calcd. for. C13H16N2O S: C,62.87; H, 6.49; N, 11.28. Found: C, 62.70; H, 6.46; N, 11.27. Mass spectrum (EI, M.+) m/z 248.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05554607 |
| 出典データセット | uspto-grants-1996_09 |
| ORD ID | ord-82654d64920e4ba5916857501b3a0d25 |
| 出典メモ | uspto-grants-1996_09 |