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Triethylamine → 3-(2,6-Dimethylphenyl)-1-isopropyl-2-thioxo-imidazolidin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2,6-Xylyl isothiocyanate | HCID 87976 | — |
| 反応物 | NoName_76 | HCID 414244 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 3-(2,6-Dimethylphenyl)-1-isopropyl-2-thioxo-imidazolidin-4-one | HCID 4852838 | 49.2% |
反応手順
The title compound was prepared by the procedure described in Example 45 using 16.3 g of 2,6-dimethylphenyl-isothiocyanate, 21.2 g of N-isopropyl glycine, 21.0 g of triethyl amine, and 300 mL of chloroform. Crystallization from ethanol afforded the title compound (12.9 g) as a white solid, m.p. 135°-137° C. Anal. Calcd. for. C14H18N2O S: C, 64.09; H, 6.92; N, 10.68. Found: C, 63.99; H, 6.72; N, 10.67. Mass spectrum (+FAB, I M+H]+) m/z 263.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05554607 |
| 出典データセット | uspto-grants-1996_09 |
| ORD ID | ord-ffb5a176460d46a090eac82120bfd0eb |
| 出典メモ | uspto-grants-1996_09 |