Ethyl 4-amino-4-(3-methoxyphenyl)butanoate → 5-(3-Methoxyphenyl)-2-pyrrolidinone

HRID 742558ノート

反応式

HRID 742558 の反応式
[NH2:1][CH:2]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH3:17])[CH:11]=1)[CH2:3][CH2:4][C:5](OCC)=[O:6]>C1(C)C=CC=CC=1>[CH3:17][O:16][C:12]1[CH:11]=[C:10]([CH:2]2[NH:1][C:5](=[O:6])[CH2:4][CH2:3]2)[CH:15]=[CH:14][CH:13]=1

参加物

3

反応物 1

HCID 23361303Ethyl 4-amino-4-(3-methoxyphenyl)butanoate

生成物 1

HCID 152932255-(3-Methoxyphenyl)-2-pyrrolidinone収率 90%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Ethyl 4-amino-4-(3-methoxyphenyl)butanoate (9.39 g) was dissolved in toluene (50 ml) and the solution heated under reflux for 0.5 hr to 1.0 hr. The mixture was cooled to ambient temperature, the precipitate was collected, and the filtrate was concentrated. The residue was recrystallized from ether to give 6.80 g (90%) of product, mp 84°-85° C.

後処理

  1. temperaturethe solution heated
  2. temperatureunder reflux for 0.5 hr to 1.0 hr
  3. customthe precipitate was collected
  4. concentrationthe filtrate was concentrated
  5. customThe residue was recrystallized from ether

出典と根拠

ORDレコード
ord-31d08ce1e1d94e4bbc65d395b514e045
出典データセット
uspto-grants-1996_09
特許番号
US05554750

反応ノート

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