Water → 2-(4-Neopentylamino-3-nitrophenyl)benzoxazole

HRID 74256

反応式

HRID 74256 の反応式
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][C:3]=1[N+:17]([O-:19])=[O:18].C(=O)([O-])[O-].[K+].[K+].[CH2:26]([NH2:31])[C:27]([CH3:30])([CH3:29])[CH3:28].O>C(O)C>[CH2:26]([NH:31][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][C:3]=1[N+:17]([O-:19])=[O:18])[C:27]([CH3:30])([CH3:29])[CH3:28]

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 79882NeopentylamineHCID 219909702-(4-Fluoro-3-nitrophenyl)benzoxazole

生成物 1

HCID 674990142-(4-Neopentylamino-3-nitrophenyl)benzoxazole収率 97.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a suspension of 2-(4-fluoro-3-nitrophenyl)benzoxazole (see Working Example 15-2) (200 mg, 0.774 mmol) in ethanol (5 mL) was added potassium carbonate (214 mg, 1.55 mmol) and neopentylamine (135 mg, 1.55 mmol), and this was heated to reflux for 4 hours. After the reaction was complete, this was cooled to room temperature, water was added, and after the precipitated crystals were filtered and washed with water, they were dried to yield the title compound (245 mg, 97% yield).

後処理

  1. temperaturethis was heated
  2. temperatureto reflux for 4 hours
  3. filtrationafter the precipitated crystals were filtered
  4. washwashed with water, they
  5. customwere dried

出典と根拠

ORDレコード
ord-6cd0155b2f8b4c6da92d942606137c28
出典データセット
uspto-grants-2014_09
特許番号
US08829035B2

関連ノート

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