関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Cyclododecane | HCID 9268 | — |
| 反応物 | alpha-Methylbutyrolactone | HCID 98323 | — |
| 反応物 | Methyl 3-cyano-2-methylpropionate | HCID 3016095 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Methyl 2-methyl-4-hydroxybutyrate | HCID 12953943 | — |
反応手順
A mixture of 0.05 mmol RuHCi(H2)(PCy3)2, 0.54 mmol methyl-3-cyanoisobutyrate (prepared by addition of HCN to methyl methacrylate), 17.7 g THF, 15.3 g water, and 0.0596 g cyclododecane (internal standard for gc analysis) was stirred in an autoclave and heated to 100° C. under 7000 kPa H2. After 3.2 hours, the nitrile was completely and cleanly converted to methyl-butyrolactone, which formed by transesterification/cyclization of the intermediate hydroxyester, methyl 2-methyl-4-hydroxybutyrate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05554778 |
|---|
| 出典データセット | uspto-grants-1996_09 |
|---|
| ORD ID | ord-a4626a5968684a6a9d28ce7c4909b112 |
|---|
| 出典メモ | uspto-grants-1996_09 |
|---|
