Hydrochloric Acid → N,N-Dimethyl-3-[2-(4-phenylbutyl)phenoxy]propylamine hydrochloride

反応式

[ClH:1].[CH3:2][N:3]([CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][CH2:16][CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH3:4]>O1CCOCC1.C(OCC)(=O)C>[ClH:1].[CH3:2][N:3]([CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][CH2:16][CH2:17][CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)[CH3:4]

参加物

実験手順

0.18 ml of a 4N solution of hydrogen chloride in dioxane was added to a solution of 210 mg of N,N-dimethyl-3-[2-(4-phenylbutyl)phenoxy]propylamine [prepared as described in step (a) above] in 5 ml of ethyl acetate, and the resulting mixture was concentrated by distillation under reduced pressure. The resulting residue was dissolved in a small amount of ethyl acetate, and the resulting solution was allowed to stand at room temperature. The crystals which precipitated were collected by filtration to give 210 mg (yield 89%) of the title compound as colorless crystals, melting at 104°-106° C.