Hydrochloric Acid → N,N-Dimethyl-2-[2-(4-phenylbutyl)phenoxy]ethylamine hydrochloride

HRID 743175ノート

反応式

HRID 743175 の反応式
[ClH:1].[CH3:2][N:3]([CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH3:4]>O1CCOCC1.C(OCC)(=O)C>[ClH:1].[CH3:2][N:3]([CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][CH2:16][CH2:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[CH3:4]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 15389029N,N-Dimethyl-2-[2-(4-phenylbutyl)phenoxy]ethylamine

生成物 1

HCID 19423977N,N-Dimethyl-2-[2-(4-phenylbutyl)phenoxy]ethylamine hydrochloride収率 93%

試薬・触媒・溶媒 2

HCID 8857Ethyl Acetate溶媒HCID 312751,4-Dioxane溶媒

実験手順

0.39 ml of a 4N solution of hydrogen chloride in dioxane was added to a solution of 230 mg of N,N-dimethyl-2-[2-(4-phenylbutyl)phenoxy]ethylamine [prepared as described in step (a) above] in 5 ml of ethyl acetate, and the resulting mixture was allowed to stand at room temperature. The crystals which precipitated were collected by filtration, washed with ethyl acetate and dried in vacuo, to give 241 mg (yield 93%) of the title compound as colorless crystals, melting at 170°-173° C.

後処理

  1. customto stand at room temperature
  2. customThe crystals which precipitated
  3. filtrationwere collected by filtration
  4. washwashed with ethyl acetate
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-2c61e95625014ed283fbc4d5ac7ac602
出典データセット
uspto-grants-1996_09
特許番号
US05556864

反応ノート

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