Hydrochloric Acid → 1-{2-[4-(2-Chlorophenyl)butyl]phenoxy}-3-dimethylamino-2-propanol hydrochloride
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:25]=[CH:24][CH:23]=[CH:22][C:13]=1[O:14][CH2:15][CH:16]([OH:21])[CH2:17][N:18]([CH3:20])[CH3:19].Cl>>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:25]=[CH:24][CH:23]=[CH:22][C:13]=1[O:14][CH2:15][CH:16]([OH:21])[CH2:17][N:18]([CH3:19])[CH3:20]参加物
3
実験手順
Following a procedure similar to that described in Example 17(c), 500 mg of 1-{2-[4-(2-chlorophenyl)butyl]phenoxy}-3-dimethylamino-2-propanol [prepared as described in step (b) above] were converted to the hydrochloride by passing it through a column packed with CM Sephadex C-25 (H+ type). The crude product was purified as described in Example 17(c), to give 398 mg (yield 72%) of the title compound as a colorless oil.
後処理
- customThe crude product was purified
出典と根拠
- ORDレコード
- ord-808c8ed7059d43d2b92789f369698b74
- 出典データセット
- uspto-grants-1996_09
- 特許番号
- US05556864
反応ノート
読み込み中…