Hydrochloric Acid → 2-{2-[2-(4-Phenylbutyl)phenoxy]ethyl}piperidine hydrochloride

HRID 743238ノート

反応式

HRID 743238 の反応式
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH:10]1[CH2:15][CH2:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[CH2:24][CH2:25][CH2:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=O)(C)(C)C>O1CCOCC1>[ClH:1].[C:28]1([CH2:27][CH2:26][CH2:25][CH2:24][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[O:17][CH2:16][CH2:15][CH:10]2[CH2:11][CH2:12][CH2:13][CH2:14][NH:9]2)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 108367361-t-Butoxycarbonyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}piperidine

生成物 1

HCID 194239802-{2-[2-(4-Phenylbutyl)phenoxy]ethyl}piperidine hydrochloride収率 97%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

10 ml of a 4N solution of hydrogen chloride in dioxane were added to a solution of 1.13 g of 1-t-butoxycarbonyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}piperidine [prepared as described in step (b) above] in 10 ml of dioxane, and the resulting mixture was stirred at room temperature for 30 minutes. At the end of this time, the reaction mixture was freed from the solvent by distillation under reduced pressure. The resulting residue was washed with hexane and dried in vacuo, to give 0.94 g (yield 97%) of the title compound as a colorless oil.

後処理

  1. distillationAt the end of this time, the reaction mixture was freed from the solvent by distillation under reduced pressure
  2. washThe resulting residue was washed with hexane
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-895a9fea50b34cfea0b7205a25fe6ae1
出典データセット
uspto-grants-1996_09
特許番号
US05556864

反応ノート

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