2-(2-Phenylethyl)phenol → 1-Methyl-2-{2-[2-(2-phenylethyl)phenoxy]ethyl}pyrrolidine

HRID 743285

反応式

HRID 743285 の反応式
[C:1]1([CH2:7][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[OH:15])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CC(C)([O-])C.[K+].Cl.Cl[CH2:24][CH2:25][CH:26]1[CH2:30][CH2:29][CH2:28][N:27]1[CH3:31]>CC(N(C)C)=O>[CH3:31][N:27]1[CH2:28][CH2:29][CH2:30][CH:26]1[CH2:25][CH2:24][O:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[CH2:8][CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 3

HCID 27490412-(2-Phenylethyl)phenolHCID 3017050Pyrrolidine, 2-(2-chloroethyl)-1-methyl-, hydrochloride (1:1)HCID 23665647Potassium tert-butoxide

生成物 1

HCID 107837421-Methyl-2-{2-[2-(2-phenylethyl)phenoxy]ethyl}pyrrolidine収率 34.2%

試薬・触媒・溶媒 1

HCID 31374Dimethylacetamide溶媒

実験手順

Following a procedure similar to that described in Example 35(a), 900 mg of 2-(2-phenylethyl)phenol (prepared as described in Preparation 19), 1.02 g of potassium t-butoxide and 836 mg of 2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride were reacted in 10 ml of dimethylacetamide. The mixture was then worked up as described in Example 35(a), and the crude product thus obtained was purified by column chromatography through silica gel, using a 10:1 by volume mixture of methylene chloride and methanol as the eluent, to give 480 mg of the title compound as a colorless oil.

後処理

  1. customthe crude product thus obtained
  2. customwas purified by column chromatography through silica gel
  3. additionby volume mixture of methylene chloride and methanol as the eluent

出典と根拠

ORDレコード
ord-8a020ab3c56740c5abe10286f2f54da9
出典データセット
uspto-grants-1996_09
特許番号
US05556864

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