Hydrochloric Acid → 1-Methyl-2-{2-[2-(2-phenylethyl)phenoxy]ethyl}piperidine hydrochloride

反応式

[ClH:1].[CH3:2][N:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH:4]1[CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C(OCC)(=O)C>O1CCOCC1>[ClH:1].[CH3:2][N:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH:4]1[CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

参加物

実験手順

0.6 ml of a 4N solution of hydrogen chloride in dioxane was added to a solution of 670 mg of 1-methyl-2-{2-[2-(2-phenylethyl)phenoxy]ethyl}piperidine [prepared as described in step (a) above] in a suitable amount of ethyl acetate, and the resulting mixture was concentrated by distillation under reduced pressure. The resulting solid residue was recrystallized from ethyl acetate, to give 350 mg (yield 47%) of the title compound as colorless crystals, melting at 128°-130° C.