Hydrochloric Acid → HCID 10384875、化合物

HRID 743365ノート

反応式

HRID 743365 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][C:11]2[CH:25]=[CH:24][CH:23]=[CH:22][C:12]=2[O:13][CH2:14][CH2:15][C@@H:16]2[CH2:20][CH2:19][CH2:18][N:17]2[CH3:21])[CH:6]=[CH:7][CH:8]=1.[ClH:26]>O1CCOCC1>[ClH:26].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][C:11]2[CH:25]=[CH:24][CH:23]=[CH:22][C:12]=2[O:13][CH2:14][CH2:15][C@@H:16]2[CH2:20][CH2:19][CH2:18][N:17]2[CH3:21])[CH:6]=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 10384876HCID 10384876、化合物

生成物 1

HCID 10384875HCID 10384875、化合物収率 81%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

0.829 g of (S)-2-(2-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}ethyl)-1-methylpyrrolidine was dissolved in 10 ml of dioxane, and 1.83 ml of a 4N solution of hydrogen chloride in dioxane was added to the solution, which was then concentrated by distillation under reduced pressure. The resulting oil was dissolved in 15 ml of ethyl acetate, and the solution was allowed to stand at room temperature. The crystals which precipitated were collected by filtration and dried in vacuo, to give 0.741 g (yield 81%) of the title compound as colorless crystals, melting at 133°-135° C.

後処理

  1. concentrationwas then concentrated by distillation under reduced pressure
  2. dissolutionThe resulting oil was dissolved in 15 ml of ethyl acetate
  3. customto stand at room temperature
  4. customThe crystals which precipitated
  5. filtrationwere collected by filtration
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-8b2ae6e0ac0849c1932b18db575dcc8b
出典データセット
uspto-grants-1996_09
特許番号
US05556864

反応ノート

読み込み中…