2,2-Diethyloxirane → 2-(3-(3-(2-Ethyl-2-hydroxybutoxy)phenyl)propyl)isoindoline-1,3-dione

HRID 74340

反応式

HRID 74340 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][N:11]2[C:19](=[O:20])[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:12]2=[O:21])[CH:5]=[CH:6][CH:7]=1.[CH2:22]([C:24]1([CH2:27][CH3:28])[CH2:26][O:25]1)[CH3:23]>>[CH2:22]([C:24]([OH:25])([CH2:27][CH3:28])[CH2:26][O:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][N:11]2[C:19](=[O:20])[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:12]2=[O:21])[CH:5]=[CH:6][CH:7]=1)[CH3:23]

参加物

3

反応物 2

HCID 2959712,2-DiethyloxiraneHCID 580275422-[3-(3-Hydroxyphenyl)propyl]isoindole-1,3-dione

生成物 1

HCID 580275942-(3-(3-(2-Ethyl-2-hydroxybutoxy)phenyl)propyl)isoindoline-1,3-dione

実験手順

Reaction of 2-(3-(3-hydroxyphenyl)propyl)isoindoline-1,3-dione with 2,2-diethyloxirane following method described in Example 18 gave 2-(3-(3-(2-ethyl-2-hydroxybutoxy)phenyl)propyl)isoindoline-1,3-dione. 1H NMR (400 MHz, CDCl3) δ 7.75-7.88 (m, 4H), 7.06 (t, J=6.8 Hz, 1H), 6.72-6.76 (m, 2H), 6.61 (d, J=8.4 Hz, 1H), 3.74 (s, 2H), 3.69 (t, J=6.4 Hz, 2H), 2.63 (t, J=7.2 Hz, 2H), 1.95-2.05 (m, 2H), 1.61-1.66 (m, 4H), 0.91 (t, J=7.6 Hz, 6H).

出典と根拠

ORDレコード
ord-fcfb2f5a6d4349f7982636b3ec4a037f
出典データセット
uspto-grants-2014_09
特許番号
US08829244B2

関連ノート

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