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2-Methoxyethanol → 2-(3-(3-(2-Methoxyethoxy)phenyl)propyl)isoindoline-1,3-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methoxyethanol | HCID 8019 | — |
| 反応物 | 2-[3-(3-Hydroxyphenyl)propyl]isoindole-1,3-dione | HCID 58027542 | — |
| 生成物 | 2-(3-(3-(2-Methoxyethoxy)phenyl)propyl)isoindoline-1,3-dione | HCID 67318002 | — |
反応手順
Mitsunobu reaction of phenol 58 with 2-methoxyethanol gave 2-(3-(3-(2-methoxyethoxy)phenyl)propyl)isoindoline-1,3-dione as a clear oil. Yield (0.225 g, 19%): 1H NMR (400 MHz, DMSO-d6) δ 7.81-7.84 (m, 2H), 7.67-7.72 (m, 2H), 7.10-7.16 (m, 1H), 6.76-6.80 (m, 2H), 6.67-6.72 (m, 1H), 4.07-4.11 (m, 2H), 3.70-3.76 (m, 4H), 3.45 (s, 3H), 2.55 (t, J=7.6 Hz, 2H), 1.98-2.05 (m, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829244B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-f061a5a1441848a6b638a0989748bec5 |
| 出典メモ | uspto-grants-2014_09 |