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1-Butanol, 4-methoxy- → 2-(3-(3-(4-Methoxybutoxy)phenyl)propyl)isoindoline-1,3-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Butanol, 4-methoxy- | HCID 8107 | — |
| 反応物 | 2-[3-(3-Hydroxyphenyl)propyl]isoindole-1,3-dione | HCID 58027542 | — |
| 生成物 | 2-(3-(3-(4-Methoxybutoxy)phenyl)propyl)isoindoline-1,3-dione | HCID 67316748 | — |
反応手順
Mitsunobu reaction of phenol 58 with 4-methoxybutanol gave 2-(3-(3-(4-methoxybutoxy)phenyl)propyl)isoindoline-1,3-dione as yellow oil. Yield (0.840 g, 66%): 1H NMR (400 MHz, CDCl3) δ 7.80-7.85 (m, 2H), 7.68-7.72 (m, 2H), 7.11-7.17 (m, 1H), 6.72-6.79 (m, 2H), 6.65 (dd, J=8.2, 2.4 Hz, 1H), 3.95 (t, J=6.2 Hz, 2H), 3.75 (t, J=6.8 Hz, 2H), 3.44 (t, J=6.4 Hz, 2H), 3.35 (s, 3H), 2.65 (t, J=7.2 Hz, 2H), 1.98-2.06 (m, 2H), 1.70-1.86 (m, 4H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829244B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-0e2cabaf652c431e957d7130f47d9a20 |
| 出典メモ | uspto-grants-2014_09 |