1-Benzhydryl-3-methylazetidin-3-yl methanesulfonate → 1-Benzhydryl-3-methanesulphonyloxy-3-propylazetidine
反応式
[CH:1]([N:14]1[CH2:17][C:16]([O:19][S:20]([CH3:23])(=[O:22])=[O:21])([CH3:18])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:24](N1CC(O)(CCC)C1)(C1C=CC=CC=1)[C:25]1C=CC=CC=1>>[CH:1]([N:14]1[CH2:17][C:16]([O:19][S:20]([CH3:23])(=[O:21])=[O:22])([CH2:18][CH2:24][CH3:25])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
3
実験手順
1-Benzhydryl-3-methanesulphonyloxy-3-propylazetidine was prepared under the conditions described for 1-benzhydryl-3-methanesulphonyloxy-3-methylazetidine in Patent Application EP 406,112, but starting with 2.4 g of 1-benzhydryl-3-hydroxy-3-propylazetidine. 2.4 g of 1-Benzhydryl-3-methanesulphonyloxy-3-propylazetidine are obtained in the form of a colorless solid, melting point 70° C.
後処理
- custom1-Benzhydryl-3-methanesulphonyloxy-3-propylazetidine was prepared under the conditions