Sulfuryl chloride → 3-Methoxycarbonyl-4-chloro-5-difluoromethoxy-1-methylpyrazole

HRID 743687ノート

反応式

HRID 743687 の反応式
[CH3:1][O:2][C:3]([C:5]1[CH:9]=[C:8]([O:10][CH:11]([F:13])[F:12])[N:7]([CH3:14])[N:6]=1)=[O:4].S(Cl)([Cl:18])(=O)=O>C(Cl)Cl>[CH3:1][O:2][C:3]([C:5]1[C:9]([Cl:18])=[C:8]([O:10][CH:11]([F:13])[F:12])[N:7]([CH3:14])[N:6]=1)=[O:4]

参加物

4

反応物 2

HCID 24648Sulfuryl chlorideHCID 54319416Methyl 5-(difluoromethoxy)-1-methyl-1H-pyrazole-3-carboxylate

生成物 1

HCID 537351233-Methoxycarbonyl-4-chloro-5-difluoromethoxy-1-methylpyrazole

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2.1 g (10 mmole) 3-Methoxycarbonyl-5-difluoromethoxy-1-methylpyrazole, dissolved in 30 ml methylene chloride, was treated with 1.35 g (10 mmole) sulfuryl chloride and stirred for 10 minutes at room temperature. It was then concentrated and recrystallised from diisopropyl ether/ethyl acetate.

後処理

  1. concentrationIt was then concentrated
  2. customrecrystallised from diisopropyl ether/ethyl acetate

出典と根拠

ORDレコード
ord-62653675b6724c74a531ec7d80657dd4
出典データセット
uspto-grants-1996_09
特許番号
US05556986

反応ノート

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