1-(2-(2-(1-Benzothiophene-5-yl)ethoxy)ethyl)-3-azetidinol → 1-(2-(2-(1-Benzothiophene-5-yl)ethoxy)ethyl)-3-azetidinol hydrochloride

HRID 7437

反応式

HRID 7437 の反応式
[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][N:15]3[CH2:18][CH:17]([OH:19])[CH2:16]3)=[CH:9][C:4]=2[CH:3]=[CH:2]1.C(OCC)(=O)C.[ClH:26]>C(OCC)(=O)C>[ClH:26].[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][N:15]3[CH2:18][CH:17]([OH:19])[CH2:16]3)=[CH:9][C:4]=2[CH:3]=[CH:2]1

参加物

4

反応物 2

HCID 114042301-(2-(2-(1-Benzothiophene-5-yl)ethoxy)ethyl)-3-azetidinolHCID 21866389Hydrogen chloride-ethyl acetate

生成物 1

HCID 114042291-(2-(2-(1-Benzothiophene-5-yl)ethoxy)ethyl)-3-azetidinol hydrochloride

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

In 4.2 mL of ethyl acetate was dissolved 1.03 g of 1-{2-[2-(1-benzothiophen-5-yl)ethoxy]ethyl}-3-azetidinol, and to the solution was added 0.86 mL of a 4.76 mol/L dried hydrogen chloride-ethyl acetate solution. The resulting mixture was stirred at room temperature for 1 hour and then at 5° C. for 1 hour. The crystals precipitated were collected by filtration, washed with ethyl acetate and then dried to obtain 0.98 g of 1-{2-[2-(1-benzothiophen-5-yl)ethoxy]ethyl}-3-azetidinol hydrochloride.

後処理

  1. waitat 5° C. for 1 hour
  2. customThe crystals precipitated
  3. filtrationwere collected by filtration
  4. washwashed with ethyl acetate
  5. customdried

出典と根拠

ORDレコード
ord-9f6a0eda9df54bc286584a94be20d1da
出典データセット
uspto-grants-2006_08
特許番号
US07087594B2

関連ノート

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